Purpose The etiology of 80% of patients with primary antibody deficiency (PAD), the second
most common type of human immune system disorder after human immunodeficiency virus …

Background Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX)
syndrome is a rare inborn error of immunity caused by mutations in the forkhead box P3 …

Inborn errors of immunity are traditionally best known for enhancing susceptibility to
infections. However, allergic inflammation, among other types of immune dysregulation …

Simple Summary Children with a COVID-19 infection are at risk of developing a novel
syndrome called multisystem inflammatory syndrome in children (MIS-C). This disease state …

Background Biallelic variations in the dedicator of cytokinesis 8 (DOCK8) gene cause a
combined immunodeficiency with eczema, recurrent bacterial and viral infections, and …

Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and
infected cells, which makes them unique 'off-the-shelf'candidates for a new generation of …

DOCK 8 immunodeficiency syndrome (DIDS) is a progressive combined immunodeficiency
that can be distinguished from other combined immunodeficiencies or …

Over the ages, fungi have associated with different parts of the human body and established
symbiotic associations with their host. They are mostly commensal unless there are certain …

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an
autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) …

Caspase recruitment domain (CARD) protein–B cell CLL/lymphoma 10 (BCL10)–MALT1
paracaspase (MALT1)[CBM] complexes are critical signaling adaptors that facilitate immune …