This article aims to investigate the characteristic microstructure-based failure mechanisms
observed during the fracture cutting of age-varying bovine cortical bone. To this end …

The high occurrence of distal fibula fractures among older women suggests a potential link
to impaired bone health. Here we used a multiscale imaging approach to investigate the …

Biophysical factors play a fundamental role in human embryonic development. Traditional in
vitro models of organogenesis focused on the biochemical environment and did not …

Micropetrosis develops as a result of stagnation of calcium, phosphorus and bone fluid,
which appears as highly mineralized bone area in the osteocytic perilacunar/canalicular …

The differences in bone nanomechanical properties between cortical (Ct) and trabecular
(Tb) bone remain uncertain, whereas knowing the respective contribution of each …

Cortical bone is a complex hierarchical structure consisting of biological fiber composites
with transversely isotropic constituents, whose microstructures deserve extensive study to …

The unclear and unpredictable fracture surface orientations of cortical bones have restricted
the deep understanding of fracture mechanisms. The multidirectional loads aggravate the …

Region-specific differences in age-related bone remodeling are known to exist. We therefore
hypothesized that the decline in tissue-level strength and post-yield strain (PYS) with age is …

Bisphosphonates [BPs] are the mainstay for osteoporosis treatment. They suppress bone
resorption/remodeling, preventing bone loss. However, BPs also suppress the beneficial …