The cellular localization and development of neuronal intranuclear inclusions (NIIs) in cortex
and striatum of R6/2 HD transgenic mice were studied to ascertain the relationship of NIIs to …

Huntington's disease is a devastating progressive neurodegenerative illness characterized
by massive neuronal loss in the striatum. It is caused by the presence of an expanded CAG …

Changes in BDNF expression after different types of brain insults are related to
neuroprotection, stimulation of sprouting, and synaptic reorganization. In the cerebral cortex …

Transgenic mouse models of Huntington's disease (HD) were examined following the onset
of overt behavioral symptoms. The HD transgenic mice demonstrated profound striatal …

We used behavioral testing and morphological methods to detail the progression of basal
ganglia neuron type‐specific pathology and the deficits stemming from them in male …

Huntington's disease is a neurodegenerative disorder characterized by the selective loss of
striatal neurons and, to a lesser extent, cortical neurons. The neurodegenerative process is …

There is morphological evidence for differential alterations in striatal medium-sized spiny
neurons (MSNs) giving rise to the direct and indirect output pathways in Huntington's …

Background: Huntington's disease (HD) is a neurological disorder caused by mutations in
the huntingtin (HTT) gene, the product of which leads to selective and progressive neuronal …

Aberrant communication between striatum, the main information processing unit of the basal
ganglia, and cerebral cortex plays a critical role in the emergence of Huntington's disease …

Huntington's disease (HD) is a noncurable and progressive autosomal-dominant
neurodegenerative disorder that results from a polyglutamine expansion in the amino …