[HTML][HTML] Liver toxicity as a limiting factor to the increasing use of immune checkpoint inhibitors

E De Martin, JM Michot, O Rosmorduc, C Guettier… - JHEP Reports, 2020 - Elsevier
Immune checkpoint inhibitors (ICIs) improve clinical outcomes in patients suffering from
different types of cancer. Liver toxicity is one of the immune-related adverse events …

A review of cancer immunotherapy toxicity: immune checkpoint inhibitors

N Chhabra, J Kennedy - Journal of Medical Toxicology, 2021 - Springer
Cancer immunotherapy, which leverages features of the immune system to target neoplastic
cells, has revolutionized the treatment of cancer. The use of these therapies has rapidly …

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

RJ Fontana, I Liou, A Reuben, A Suzuki, MI Fiel… - Hepatology, 2023 - journals.lww.com
There are currently more than 1000 prescription medications available for use in the United
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …

Lessons to be learnt from real-world studies on immune-related adverse events with checkpoint inhibitors: a clinical perspective from pharmacovigilance

E Raschi, M Gatti, F Gelsomino, A Ardizzoni… - Targeted Oncology, 2020 - Springer
The advent of immune checkpoint inhibitors (ICIs) caused a paradigm shift both in drug
development and clinical practice; however, by virtue of their mechanism of action, the …

Immune checkpoint inhibitors in hepatocellular carcinoma: current progresses and challenges

HT Liu, MJ Jiang, ZJ Deng, L Li, JL Huang… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world
and its incidence is increasing in many countries. In recent years, with the deepening …

Immunosuppressive nanoparticles for management of immune-related adverse events in liver

S Shen, H Dai, Z Fei, Y Chai, Y Hao, Q Fan, Z Dong… - ACS …, 2021 - ACS Publications
Immune checkpoint blockade (ICB) therapy has been considered as an effective way to
boost immune cells to recognize and attack tumors. However, side effects known as immune …

Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

GL Ma, WF Lin - Military Medical Research, 2023 - Springer
Immune checkpoint blockade (ICB) therapy for cancer has achieved great success both in
clinical results and on the market. At the same time, success drives more attention from …

Polymeric micelles in cancer immunotherapy

Z Wan, R Zheng, P Moharil, Y Liu, J Chen, R Sun… - Molecules, 2021 - mdpi.com
Cancer immunotherapies have generated some miracles in the clinic by orchestrating our
immune system to combat cancer cells. However, the safety and efficacy concerns of the …

Risk of lichen sclerosus and lichen planus in patients receiving immune checkpoint inhibitors

A Alharbi, A Khobrani, A Noor, W Alghamdi… - International journal of …, 2022 - mdpi.com
Introduction: Immune checkpoint inhibitors (ICIs) are recommended for various types of
cancer. On the other hand, these ICIs may cause immune-related adverse events (irAEs) …

[HTML][HTML] The current status of steroid-refractory immune-checkpoint-inhibitor-related hepatotoxicity

H Xing, Y Wang, B Qu, Q Wei, C Li, C Pan, H Li - Translational Oncology, 2023 - Elsevier
ICI-related hepatotoxicity (IRH) is becoming more and more common as immune checkpoint
inhibitors (ICIs) have begun to be increasingly approved and used in combination with other …