Primary aldosteronism: renaissance of a syndrome

WF Young - Clinical endocrinology, 2007 - Wiley Online Library
Great strides have been made in our understanding of the pathophysiology of primary
aldosteronism syndrome since Conn's description of the clinical presentation of a patient …

Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism

J Rege, S Bandulik, K Nanba, C Kosmann… - Nature Genetics, 2023 - nature.com
Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study

S Douma, K Petidis, M Doumas, P Papaefthimiou… - The Lancet, 2008 - thelancet.com
Background Results of several studies published since 1999 suggest that primary
hyperaldosteronism (also known as Conn's syndrome) affects more than 10% of people with …

Adrenalectomy lowers incident atrial fibrillation in primary aldosteronism patients at long term

GP Rossi, G Maiolino, A Flego, A Belfiore, G Bernini… - …, 2018 - Am Heart Assoc
Primary aldosteronism (PA) causes cardiovascular damage in excess to the blood pressure
elevation, but there are no prospective studies proving a worse long-term prognosis in …

Influence of baseline and worsening renal function on efficacy of spironolactone in patients with severe heart failure: insights from RALES (Randomized Aldactone …

O Vardeny, DH Wu, A Desai, P Rossignol… - Journal of the American …, 2012 - jacc.org
Objectives: This study investigated the influence of baseline and worsening renal function
(WRF) on the efficacy of spironolactone in patients with severe heart failure (HF) …

[HTML][HTML] The 2020 Italian Society of Arterial Hypertension (SIIA) practical guidelines for the management of primary aldosteronism

GP Rossi, V Bisogni, AV Bacca, A Belfiore… - International Journal of …, 2020 - Elsevier
Background and aim Considering the amount of novel knowledge generated in the last five
years, a team of experienced hypertensionlogists was assembled to furnish updated clinical …

Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension

MN Pratt-Ubunama, MK Nishizaka, RL Boedefeld… - Chest, 2007 - Elsevier
Objective: Obstructive sleep apnea (OSA) and primary aldosteronism are common in
subjects with resistant hypertension; it is unknown, however, if the two disorders are causally …

Primary aldosteronism: changing definitions and new concepts of physiology and pathophysiology both inside and outside the kidney

M Stowasser, RD Gordon - Physiological reviews, 2016 - journals.physiology.org
In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Cardiovascular and cerebrovascular comorbidities of hypokalemic and normokalemic primary aldosteronism: results of the German Conn's Registry

E Born-Frontsberg, M Reincke, LC Rump… - The Journal of …, 2009 - academic.oup.com
Context: Primary aldosteronism (PA) is associated with vascular end-organ damage.
Objective: Our objective was to evaluate differences regarding comorbidities between the …

Quality of life in primary aldosteronism: a comparative effectiveness study of adrenalectomy and medical treatment

M Velema, T Dekkers, A Hermus… - The Journal of …, 2018 - academic.oup.com
Context In primary aldosteronism (PA), two subtypes are distinguished: aldosterone-
producing adenoma (APA) and bilateral adrenal hyperplasia (BAH). In general, these are …