Background Many medications (including most antihypertensives) and physiological factors
affect the aldosterone/renin ratio (ARR) when screening for primary aldosteronism (PA). We …

Context: Unilateral adrenalectomy is the therapy of choice in aldosterone-producing
adenoma (APA). Zona glomerulosa (ZG) insufficiency causing hyperkalemia after …

Primary aldosteronism (PA) is one of the common forms of curable hypertension. Recent
views have suggested that PA is far from being relatively benign, as it was previously …

Accumulating evidence has indicated the potential contributions of aldosterone and
mineralocorticoid receptor (MR) to the pathophysiology of cardiovascular disease (CVD) …

Objective Adrenal vein sampling (AVS) is considered the gold standard in the differential
diagnosis of primary aldosteronism (PA), but success rates vary between centers. We …

Mineralocorticoid receptor antagonists (MRAs) are commonly used to reduce blood
pressure, left-ventricular hypertrophy, and urinary albumin excretion in patients with …

Context: Elevated urinary albumin excretion has been reported in primary aldosteronism
and might partially reflect reversible abnormalities initiated by glomerular hyperfiltration …

Background: Measurement of quality of life (QOL) allows assessment of the impact of a
disease or treatment from the patient's perspective, including need for social, emotional, or …

Background Primary aldosteronism is much more common than previously held; it implies
an excessive organ damage to the heart, vessels and kidney, which translates into an …

The past two decades have witnessed a striking paradigm shift with respect to our
understanding of the widespread effects of aldosterone. There is substantive evidence that …