Plasma renin levels can be used to classify hypertension. A significant proportion of
hypertensive individuals display a low‐renin profile and thus low‐renin hypertension (LRH) …

The mineralocorticoid receptor (MR) is a ligand dependent transcription factor. MR has been
traditionally associated with the control of water and electrolyte homeostasis in order to keep …

Primary aldosteronism is common and contributes to adverse cardiovascular, kidney, and
metabolic outcomes. When instituted early and effectively, targeted therapies can mitigate …

Background: The renal damage that is present in primary aldosteronism might reflect
functional and potentially reversible abnormalities that are initiated by glomerular …

BACKGROUND: Autonomous secretion of aldosterone in patients with primary
aldosteronism increases glomerular filtration rate and causes kidney damage. The influence …

Context: Although confirmatory testing to verify aldosterone excess is a key step in the
diagnosis of primary aldosteronism (PA), there is no consensus as to whether it is always …

Background Aldosterone has been shown to substantially contribute to the accumulation of
different types of collagen fibers and growth factors in the arterial wall, which increase wall …

Superselective adrenal artery embolization (SAAE) is an effective treatment for patients with
primary aldosteronism (PA). However, the impact of SAAE on renal function in the PA …

The rapid progression of chronic kidney disease and higher incidence of cardiovascular
complications are well known in patients with hyperaldosteronism. However, detailed renal …

Objective Primary aldosteronism (PA) has deleterious effects on kidney function
independent of blood pressure levels. Up to now, data on effectiveness of different PA …