Context: Adrenal venous sampling is recommended to assess whether aldosterone
hypersecretion is lateralized in patients with primary aldosteronism. However, this procedure …

Objectives: In experimental animal models, exogenous aldosterone excess has been linked
to the progression of renal disease. However, the evidence of an increased risk of renal …

Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor
(MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads …

Mineralocorticoid receptor (MR) antagonists, for example, spironolactone and eplerenone,
are in clinical use to treat hypertension. Increasing evidence suggests that mineralocorticoid …

Metabolic syndrome is an important risk factor for proteinuria and chronic kidney disease
independent of diabetes and hypertension; however, the underlying mechanisms have not …

The identification of several germline and somatic ion channel mutations in aldosterone-
producing adenomas (APAs) and detection of cell clusters that can be responsible for …

Objectives: To assess the prevalence of primary aldosteronism and its association with
cardiometabolic complications in patients with resistant and refractory hypertension …

For many years primary aldosteronism was considered a relatively benign form of
hypertension. This assumption reflects the primacy accorded to elevated levels of …

Primary aldosteronism (PA), a common, albeit markedly underdiagnosed cause of curable
arterial hypertension, is characterized by plasma levels of aldosterone that are inappropriate …

Context: Primary aldosteronism (PA) is associated with vascular end organ damage.
Objective: We evaluated the newly established German Conn's Registry for evidence of …