Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease leading to
multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly …

Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high
heritability, shows differences in prevalence, severity and age of onset among different …

Sjögren's disease is a complex autoimmune disease with twelve established susceptibility
loci. This genome-wide association study (GWAS) identifies ten novel genome-wide …

Systemic lupus erythematosus is the prototypical systemic autoimmune disease, as it is
characterized both by protean multi-organ system manifestations and by the uniform …

Objective Systemic lupus erythematosus (SLE) is a highly heritable complex disorder with
heterogeneous clinical manifestations. In this study, we aimed to identify the genetic risk …

Objective IRF5 plays a crucial role in the development of lupus. Genome‐wide association
studies have identified several systemic lupus erythematosus (SLE) risk single‐nucleotide …

A substantial proportion of the adult United States population with type 2 diabetes (T2D) are
undiagnosed, calling into question the comprehensiveness of current screening practices …

The prevalence and severity of SLE have been found to vary across populations of different
ancestries. This review explores whether these differences can be explained by the genetic …

Patients with systemic lupus erythematosus (SLE) present varied clinical manifestations,
posing a diagnostic challenge for physicians. Genetic factors substantially contribute to SLE …