Computational Study of H2S Release in Reactions of Diallyl Polysulfides with Thiols

YR Cai, CH Hu - The Journal of Physical Chemistry B, 2017 - ACS Publications
Hydrogen sulfide (H2S) is a gasotransmitter molecule recognized for its role in cell
signaling. Garlic-derived polysulfides including diallyl disulfide (DADS) and diallyl trisulfide …

Polysulfide and hydrogen sulfide ameliorate cisplatin-induced nephrotoxicity and renal inflammation through Persulfidating STAT3 and IKKβ

HJ Sun, B Leng, ZY Wu, JS Bian - International Journal of Molecular …, 2020 - mdpi.com
Cisplatin, a widely used chemotherapy for the treatment of various tumors, is clinically
limited due to its extensive nephrotoxicity. Inflammatory response in tubular cells is a driving …

The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS‐CoV‐2 and Its Potential Cell Surface Receptors

J Dai, X Teng, S Jin, Y Wu - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
The ongoing coronavirus disease 2019 (COVID‐19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is posing a great threat to the global …

Hydrogen sulfide in the adipose tissue—physiology, pathology and a target for pharmacotherapy

J Bełtowski, A Jamroz-Wiśniewska - Molecules, 2016 - mdpi.com
Hydrogen sulfide (H2S) is synthesized in the adipose tissue mainly by cystathionine γ-lyase
(CSE). Several studies have demonstrated that H2S is involved in adipogenesis, that is the …

Activity-Based Proteomic Identification of the S-Thiolation Targets of Ajoene in MDA-MB-231 Breast Cancer Cells

DA Kusza, R Hunter, G Schäfer, M Smith… - Journal of Agricultural …, 2022 - ACS Publications
Garlic is a medicinal plant and spice that has been used for millennia for its health-
promoting effects. These medicinal properties are associated with low molecular weight …

Hydrogen sulfide inhibits inflammatory pain and enhances the analgesic properties of delta opioid receptors

A Porta, L Rodríguez, X Bai, G Batallé, G Roch… - Antioxidants, 2021 - mdpi.com
Chronic inflammatory pain is present in many pathologies and diminishes the patient's
quality of life. Moreover, most current treatments have a low efficacy and significant side …

Natural scaffolds in anticancer therapy and precision medicine

A Mazumder, C Cerella, M Diederich - Biotechnology advances, 2018 - Elsevier
The diversity of natural compounds is essential for their mechanism of action. The source,
structures and structure activity relationship of natural compounds contributed to the …

Prospective medicinal plants and their phytochemicals shielding autoimmune and cancer patients against the SARS-CoV-2 pandemic: A special focus on matcha

CJ Kiriacos, MR Khedr, M Tadros… - Frontiers in Oncology, 2022 - frontiersin.org
Background Being “positive” has been one of the most frustrating words anyone could hear
since the end of 2019. This word had been overused globally due to the high infectious …

Hydrogen sulfide signaling in the tumor microenvironment: implications in cancer progression and therapy

JA Machado-Neto, ARA Cerqueira… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Cancer is a complex and heterotypic structure with a spatial organization that
contributes to challenges in therapeutics. Enzymes associated with producing the …

Rapid capture and killing of bacteria by lyophilized nFeS-Hydrogel for improved healing of infected wounds

B Shen, W Li, Y Wang, S Cheng, X Wang, L Zhu… - Biomaterials …, 2023 - Elsevier
Due to their antibacterial activity, sulfur-containing nanomaterials are increasingly being
developed into nanodrugs against bacterial infection. Nano iron sulfide (nFeS) is a new …