[HTML][HTML] The role of hepatokines in NAFLD

N Stefan, F Schick, AL Birkenfeld, HU Häring, MF White - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus

A Kautzky-Willer, J Harreiter, G Pacini - Endocrine reviews, 2016 - academic.oup.com
The steep rise of type 2 diabetes mellitus (T2DM) and associated complications go along
with mounting evidence of clinically important sex and gender differences. T2DM is more …

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

RCR Meex, MJ Watt - Nature Reviews Endocrinology, 2017 - nature.com
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …

Understanding weight gain at menopause

SR Davis, C Castelo-Branco, P Chedraui… - …, 2012 - Taylor & Francis
Objective The aim of this review was to summarize the literature regarding the impact of the
menopause transition on body weight and body composition. Methods We conducted a …

The role of hepatokines in metabolism

N Stefan, HU Häring - Nature Reviews Endocrinology, 2013 - nature.com
The liver is known to be involved in the natural history of the ongoing epidemics of type 2
diabetes mellitus and cardiovascular disease. In particular, the liver has a role in increased …

Testosterone in women—the clinical significance

SR Davis, S Wahlin-Jacobsen - The lancet Diabetes & …, 2015 - thelancet.com
Testosterone is an essential hormone for women, with physiological actions mediated
directly or via aromatisation to oestradiol throughout the body. Despite the crucial role of …

Novel insights in SHBG regulation and clinical implications

R Simó, C Sáez-López, A Barbosa-Desongles… - Trends in Endocrinology …, 2015 - cell.com
Sex hormone-binding globulin (SHBG) is produced and secreted by the liver into the
bloodstream where it binds sex steroids and regulates their bioavailability. Traditionally …

Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease

VWS Wong, GLH Wong, GWK Yip, AOS Lo… - Gut, 2011 - gut.bmj.com
Objective Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome and is associated with cardiovascular risk. The aim of this study was to determine …

Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots

S Hocking, D Samocha-Bonet, KL Milner… - Endocrine …, 2013 - academic.oup.com
Human adiposity has long been associated with insulin resistance and increased
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …

Sex hormone-binding globulin and type 2 diabetes mellitus

TN Le, JE Nestler, JF Strauss, EP Wickham - Trends in Endocrinology & …, 2012 - cell.com
Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and
environmental factors that potentially contribute to the pathophysiology of type 2 diabetes …