Molecular aspects of age-related cognitive decline: the role of GABA signaling

JA McQuail, CJ Frazier, JL Bizon - Trends in molecular medicine, 2015 - cell.com
Alterations in inhibitory interneurons contribute to cognitive deficits associated with several
psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ …

Impact of aging brain circuits on cognition

RD Samson, CA Barnes - European journal of neuroscience, 2013 - Wiley Online Library
Brain networks that engage the hippocampus and prefrontal cortex are central for enabling
effective interactions with our environment. Some of the cognitive processes that these …

[HTML][HTML] Distinct brain and behavioral benefits from cognitive vs. physical training: a randomized trial in aging adults

SB Chapman, S Aslan, JS Spence… - Frontiers in human …, 2016 - frontiersin.org
Insidious declines in normal aging are well-established. Emerging evidence suggests that
non-pharmacological interventions, specifically cognitive and physical training, may counter …

[HTML][HTML] Hypertension and age-related cognitive impairment: common risk factors and a role for precision aging

M Hay, C Barnes, M Huentelman, R Brinton… - Current Hypertension …, 2020 - Springer
Abstract Purpose of Review Precision Aging® is a novel concept that we have recently
employed to describe how the model of precision medicine can be used to understand and …

Cognitive aging is associated with redistribution of synaptic weights in the hippocampus

EW Buss, NJ Corbett, JG Roberts… - Proceedings of the …, 2021 - National Acad Sciences
Behaviors that rely on the hippocampus are particularly susceptible to chronological aging,
with many aged animals (including humans) maintaining cognition at a young adult-like …

[HTML][HTML] Precision aging: applying precision medicine to the field of cognitive aging

L Ryan, M Hay, MJ Huentelman, A Duarte… - Frontiers in aging …, 2019 - frontiersin.org
The current “one size fits all” approach to our cognitive aging population is not adequate to
close the gap between cognitive health span and lifespan. In this review article, we present …

[HTML][HTML] Self-reported increased confusion or memory loss and associated functional difficulties among adults aged≥ 60 years—21 states, 2011

ML Adams, AJ Deokar, LA Anderson… - Morbidity and Mortality …, 2013 - ncbi.nlm.nih.gov
Declines in cognitive function vary among persons and can include changes in attention,
memory, learning, executive function, and language capabilities that negatively affect quality …

Nutraceutical intervention improves older adults' cognitive functioning

BJ Small, KS Rawson, C Martin, SL Eisel… - Rejuvenation …, 2014 - liebertpub.com
Interventions to improve the cognitive health of older adults are of critical importance. In the
current study, we conducted a double-blind, placebo-controlled clinical trial using a pill …

The development of a manual-based digital memory notebook intervention with case study illustrations

LA Chudoba, AS Church, JB Dahmen… - Neuropsychological …, 2020 - Taylor & Francis
There is currently a need to identify feasible and effective interventions to help older
individuals suffering from memory loss maintain functional independence and quality of life …

Relation Between Smoking Status and Subjective Cognitive Decline in Middle Age and Older Adults: A Cross-Sectional Analysis of 2019 Behavioral Risk Factor …

JI Rajczyk, A Ferketich, JJ Wing - Journal of Alzheimer's …, 2023 - content.iospress.com
Background: Smoking status may influence subjective cognitive decline (SCD); however,
few studies have evaluated this association. Objective: To assess whether smoking status is …