Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for
treatment resistance and increased cardiovascular risk. Here we perform a genome-wide …

Primary aldosteronism is an underdiagnosed cause of hypertension. Although inadequate
screening is one reason for underdiagnosis, another important contributor is that clinicians …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

Unilateral primary aldosteronism is the most common surgically correctable form of
endocrine hypertension and is usually differentiated from bilateral forms by adrenal venous …

Context: Primary aldosteronism (PA) is associated with vascular end-organ damage.
Objective: Our objective was to evaluate differences regarding comorbidities between the …

Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations
in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma …

Context Adrenal venous sampling (AVS) is the key test for subtyping primary aldosteronism
(PA), but its interpretation varies widely across referral centers and this can adversely affect …

Although the aldosterone/renin ratio (ARR) is the most reliable screening test for primary
aldosteronism, false positives and negatives occur. Dietary salt restriction, concomitant …

Inappropriate aldosterone and parathyroid hormone (PTH) secretion is strongly linked with
development and progression of cardiovascular (CV) disease. Accumulating evidence …