The endocannabinoid system: a potential target for the treatment of various diseases

H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Therapeutic potential of cannabis, cannabidiol, and cannabinoid-based pharmaceuticals

CA Legare, WM Raup-Konsavage, KE Vrana - Pharmacology, 2022 - karger.com
Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation

DM Kopustinskiene, R Masteikova, R Lazauskas… - Antioxidants, 2022 - mdpi.com
Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since
ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9 …

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The effects of cannabis among adults with chronic pain and an overview of general harms: a systematic review

SM Nugent, BJ Morasco, ME O'Neil… - Annals of internal …, 2017 - acpjournals.org
Background: Cannabis is increasingly available for the treatment of chronic pain, yet its
efficacy remains uncertain. Purpose: To review the benefits of plant-based cannabis …

Endocannabinoid signaling at the periphery: 50 years after THC

M Maccarrone, I Bab, T Bíró, GA Cabral, SK Dey… - Trends in …, 2015 - cell.com
In 1964, the psychoactive ingredient of Cannabis sativa, Δ 9-tetrahydrocannabinol (THC),
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …

Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of …

AN Ananthakrishnan, GG Kaplan… - The lancet …, 2022 - thelancet.com
Environmental and lifestyle factors play an important role in the natural history of Crohn's
disease and ulcerative colitis. A group of international experts from the International …

Effect of lifestyle factors on outcomes in patients with inflammatory bowel diseases

JJ Rozich, A Holmer, S Singh - … journal of the American College of …, 2020 - journals.lww.com
Various lifestyle factors including physical activity and obesity, stress, sleep, and smoking
may modify the risk of developing inflammatory bowel diseases (IBDs). In patients with …

Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment

A Stasiłowicz, A Tomala, I Podolak… - International journal of …, 2021 - mdpi.com
Cannabis sativa L. turned out to be a valuable source of chemical compounds of various
structures, showing pharmacological activity. The most important groups of compounds …

Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?

V Martínez, A Iriondo De-Hond, F Borrelli… - International Journal of …, 2020 - mdpi.com
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …