Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
M Severa, RA Diotti, MP Etna, F Rizzo, S Fiore… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key
role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill …
role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill …
Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4+ T Cell Responses
Given the current coronavirus disease 2019 (COVID-19) pandemic, coinfection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) is a …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) is a …
Excessive matrix metalloproteinase-1 and hyperactivation of endothelial cells occurred in COVID-19 patients and were associated with the severity of COVID-19
F Syed, W Li, RF Relich, PM Russell… - The Journal of …, 2021 - academic.oup.com
Background Systemic vascular injury occurs in coronavirus disease 2019 (COVID-19)
patients; however, the underlying mechanisms remain unknown. Methods To clarify the role …
patients; however, the underlying mechanisms remain unknown. Methods To clarify the role …
Role of CCL2/CCR2 axis in the pathogenesis of COVID-19 and possible Treatments: All options on the Table
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …
Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion
One and half year following the occurrence of COVID-19 pandemic, significant efforts from
laboratories all over the world generated a huge amount of data describing the prototypical …
laboratories all over the world generated a huge amount of data describing the prototypical …
New genetic and epigenetic insights into the chemokine system: The latest discoveries aiding progression toward precision medicine
H Xu, S Lin, Z Zhou, D Li, X Zhang, M Yu… - Cellular & Molecular …, 2023 - nature.com
Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …
[PDF][PDF] Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity
AT Ambikan, H Yang, S Krishnan, SS Akusjärvi… - Cell systems, 2022 - cell.com
The clinical outcome and disease severity in coronavirus disease 2019 (COVID-19) are
heterogeneous, and the progression or fatality of the disease cannot be explained by a …
heterogeneous, and the progression or fatality of the disease cannot be explained by a …
[HTML][HTML] Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients
Mucosal barrier alterations may play a role in the pathogenesis of several diseases,
including COVID-19. In this study we evaluate the association between bacterial …
including COVID-19. In this study we evaluate the association between bacterial …
[PDF][PDF] A diminished immune response underlies age-related SARS-CoV-2 pathologies
Morbidity and mortality in response to SARS-CoV-2 infection are significantly elevated in
people of advanced age. To understand the underlying biology of this phenotype, we utilize …
people of advanced age. To understand the underlying biology of this phenotype, we utilize …
The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …