Stress is defined as a state of threatened or perceived as threatened homeostasis. The well-
tuned coordination of the stress response system is necessary for an organism to respond to …

Background Growing evidence suggests that epigenetic modification is vital in biological
processes of depression. Findings from studies exploring the associations between DNA …

Background Adolescent non-suicidal self-injury (NSSI) is common and adolescence is the
most common period of first self-injury, and the occurrence of NSSI is influenced by negative …

Abstract Background Serotonin (5-hydroxytryptamine, 5-HT) signaling is involved in
neurodevelopment, mood regulation, energy metabolism, and other physiological …

Depression negatively impacts mood, behavior, and mental and physical health. It is the
third leading cause of suicides worldwide and leads to decreased quality of life. We …

Genome-wide studies related to neurological disorders and neurodegenerative diseases
have pointed to the role of epigenetic changes such as DNA methylation, histone …

Introduction There are reports of an increase in depressive symptoms and fear during the
COVID-19 pandemic, in particular in patients with depression. This study investigates factors …

Background Affective neuroscience (AN) theory assumes the existence of seven basic
emotional systems (ie, SEEKING, ANGER, FEAR, CARE, LUST, SADNESS, PLAY) that are …

Purpose Depressive disorder is a mental health disorder with complicated etiopathogenesis.
Environmental stress and neurodevelopment combined with other factors contribute to the …

Aim: The aim of this study was to assess the interrelationships of Young's early maladaptive
schemas with indicators of specific neural emotional systems conceptualized in Panksepp's …