Some cannabinoids activate the different isoforms of PPARs (α, β and γ), as shown through
the use of reporter gene assays, binding studies, selective antagonists and knockout …

The phytocannabinoids of Cannabis sativa L. have, since ancient times, been proposed as a
pharmacological alternative for treating various central nervous system (CNS) disorders …

Cannabis sativa, commonly known as marijuana, contains a pool of secondary plant
metabolites with therapeutic effects. Besides Δ9-tetrahydrocannabinol that is the principal …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to
be a promising therapeutic target for several neurodegenerative disorders, which includes …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Growing evidence supports the pivotal role played by oxidative stress in tissue injury
development, thus resulting in several pathologies including cardiovascular, renal …

Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour,
challenges in verbal and non-verbal communication, poor socio-emotional health, and …

The endocannabinoid system plays a regulatory role in a number of physiological processes
and has been found altered in different pathological conditions, including movement …

The Janus-kinase (JAK) and signal transducer activator of transcription (STAT) signalling
pathways regulate gene expression and control various factors involved in normal …

In the early sixties, a discussion started regarding the association between Parkinson's
disease (PD) and type II diabetes mellitus (T2DM). Today, this potential relationship is still a …