A candidate antibody drug for prevention of malaria
KL Williams, S Guerrero, Y Flores-Garcia, D Kim… - Nature medicine, 2024 - nature.com
Over 75% of malaria-attributable deaths occur in children under the age of 5 years.
However, the first malaria vaccine recommended by the World Health Organization (WHO) …
However, the first malaria vaccine recommended by the World Health Organization (WHO) …
A new landscape for malaria vaccine development
AJ Laurenson, MB Laurens - PLoS Pathogens, 2024 - journals.plos.org
On October 6, 2021, the World Health Organization (WHO) recommended the first vaccine
against malaria to prevent Plasmodium falciparum malaria in children living in areas with …
against malaria to prevent Plasmodium falciparum malaria in children living in areas with …
[HTML][HTML] Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein
E Thai, R Murugan, Š Binter, CB Aschner, K Prieto… - Cell Reports, 2023 - cell.com
Summary IGHV3-33-encoded antibodies are prevalent in the human humoral response
against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33 …
against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33 …
[HTML][HTML] Anti-Immune Complex Antibodies are Elicited During Repeated Immunization with HIV Env Immunogens
S Brown, A Antanasijevic, LM Sewall, DM Garcia… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Vaccination strategies against HIV-1 aim to elicit broadly neutralizing antibodies (bnAbs)
using prime-boost regimens with HIV envelope (Env) immunogens. Early antibody …
using prime-boost regimens with HIV envelope (Env) immunogens. Early antibody …
Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies
R Murugan, A Hanke, OE Oludada, G Costa… - bioRxiv, 2024 - biorxiv.org
The protective capacity of antibodies targeting circumsporozoite protein on sporozoites of
the malaria parasite Plasmodium falciparum (PfCSP) is linked to high affinity and cross …
the malaria parasite Plasmodium falciparum (PfCSP) is linked to high affinity and cross …
Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats
A Amen, R Yoo, A Fabra-García, J Bolscher… - bioRxiv, 2023 - biorxiv.org
Circulating sexual stages of Plasmodium falciparum (Pf) can be transmitted from humans to
mosquitoes, thereby furthering the spread of malaria in the population. It is well established …
mosquitoes, thereby furthering the spread of malaria in the population. It is well established …
Super homotypic targeting by exosome surface engineering
HS Wang, T Ding, Y Liu, Y Zhou, Y Zhao, M Hayashi… - bioRxiv, 2024 - biorxiv.org
Homotypic targeting is the inherent ability of cells for preferential interaction with cells of
similar or identical types, a phenomenon commonly seen in cell adhesion, tissue formation …
similar or identical types, a phenomenon commonly seen in cell adhesion, tissue formation …