Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders

B Sun, H Sawant, A Borthakur, JC Bihl - Frontiers in Neuroscience, 2023 - frontiersin.org
Extracellular vesicles (EVs) serve as cell-to-cell and inter-organ communicators by
conveying proteins and nucleic acids with regulatory functions. Emerging evidence shows …

Intestinal changes in permeability, tight junction and mucin synthesis in a mouse model of Alzheimer's disease

J He, Y Liu, J Li, Y Zhao, H Jiang… - International …, 2023 - spandidos-publications.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-β (Aβ) in the brain. The gut/brain axis may serve a role in AD …

Impact of Donepezil Supplementation on Alzheimer's Disease-like Pathology and Gut Microbiome in APP/PS1 Mice

Y Li, M Wu, M Kong, S Sui, Q Wang, Y He, J Gu - Microorganisms, 2023 - mdpi.com
Based on published information, the occurrence and development of Alzheimer's disease
(AD) are potentially related to gut microbiota changes. Donepezil hydrochloride (DH), which …

Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease

S Dong, J Xia, F Wang, L Yang, S Xing, J Du… - European Journal of …, 2024 - Elsevier
A series of deoxyvasicinone derivatives with benzenesulfonamide substituents were
designed and synthesized to find a multifunctional anti-Alzheimer's disease (AD) drug. The …

[HTML][HTML] Evaluating serum CXCL12, sCD22, Lp-PLA2 levels and ratios as biomarkers for diagnosis of Alzheimer's disease

ZL Liu, FF Hua, L Qu, N Yan… - World Journal of …, 2024 - ncbi.nlm.nih.gov
BACKGROUND Grasping the underlying mechanisms of Alzheimer's disease (AD) is still a
work in progress, and existing diagnostic techniques encounter various obstacles …