As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than
ever given the rapid pace of modernization, which is directly associated with many of the …

Mammalian Piezo2 channels are essential for transduction of innocuous mechanical forces
by proprioceptors and cutaneous touch receptors. In contrast, mechanical responses of …

Contact lens materials have undergone significant changes over the past 20 years,
particularly with respect to the introduction of silicone hydrogel materials. Whilst this …

Multidimensional integrative data analysis of digital phenotyping is crucial for elucidating the
pathologies of multifactorial and heterogeneous diseases, such as the dry eye (DE). This …

Purpose To examine the association between modifiable lifestyle factors and dry eye
disease. Methods Three hundred and twenty-two community residents (186 females, 136 …

Corneal nerves are instrumental to maintain cornea integrity through regulation of key
physiological functions such as tear secretion, blink reflex, and neuropeptide turnover …

To design an ocular drug delivery system is challenging due to the limited space of the
ocular surface and high sensitivity of the cornea. Here, we developed a lacrimal duct drug …

Purpose To evaluate corneal subbasal nerve alterations in evaporative and aqueous-
deficient dry eye disease (DED) as compared to controls. Methods In this retrospective …

The development of novel therapies for Dry Eye Disease (DED) is formidable, and relatively
few treatments evaluated have been approved for marketing. In this report, the …