Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …

Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

This report of the WHO Working Group for Guidance on Human Challenge Studies in COVID-
19 outlines ethical standards for COVID-19 challenge studies. It includes eight Key Criteria …

Background A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum
malaria with prolonged activity would substantially advance malaria control. DSM265 is an …

The pandemic of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, poses an
extraordinary threat to global public health, socioeconomic stability, food security and other …

This open access book provides an extensive review of ethical and regulatory issues related
to human infection challenge studies, with a particular focus on the expansion of this type of …

Controlled human infection model (CHIM) studies have pivotal importance in vaccine
development, being useful for proof of concept, pathogenesis, down-selection and …

Background: The range and amount of volunteer infection studies, known as Controlled
Human Infection Model (CHMI) studies, in Low-Middle Income Countries (LMICs) is …

Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple
control interventions need to be in place simultaneously to achieve this goal. In addition to …

CMV is associated with immunosenescence and reduced vaccine responses in the elderly
(> 70 yr). However, the impact of CMV in young adults is less clear. In this study, healthy UK …