[HTML][HTML] Emerging roles of oxidative stress in brain aging and Alzheimer's disease

A Ionescu-Tucker, CW Cotman - Neurobiology of aging, 2021 - Elsevier
Reactive oxygen species (ROS) are metabolic byproducts that are necessary for
physiological function but can be toxic at high levels. Levels of these oxidative stressors …

[HTML][HTML] Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Z Cui, X Zhao, FK Amevor, X Du, Y Wang, D Li… - Frontiers in …, 2022 - frontiersin.org
Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …

[HTML][HTML] The initiation of oxidative stress and therapeutic strategies in wound healing

G Wang, F Yang, W Zhou, N Xiao, M Luo… - Biomedicine & …, 2023 - Elsevier
When the production of reactive oxygen species (ROS) is overloaded surpassing the
capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage …

ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease

DSA Simpson, PL Oliver - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer's disease

V Lau, L Ramer, MÈ Tremblay - Nature Communications, 2023 - nature.com
Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

Role of oxidative stress in depression

S Bhatt, AN Nagappa, CR Patil - Drug discovery today, 2020 - Elsevier
Highlights•The Reactive Oxygen Species have an utmost importance in progression of
Depression.•Depression is associated with lowered concentration of anti-oxidants in …

The plastic brain: neurotoxicity of micro-and nanoplastics

M Prüst, J Meijer, RHS Westerink - Particle and fibre toxicology, 2020 - Springer
Given the global abundance and environmental persistence, exposure of humans and
(aquatic) animals to micro-and nanoplastics is unavoidable. Current evidence indicates that …

Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Lipids and Alzheimer's disease

YC Kao, PC Ho, YK Tu, IM Jou, KJ Tsai - International journal of molecular …, 2020 - mdpi.com
Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …