The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …
devastating consequences. While the medical community has gained insight into the …
Immune response in COVID-19: what is next?
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …
Immunological considerations for COVID-19 vaccine strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
[HTML][HTML] Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all …
responses and COVID-19 disease severity. We completed a combined examination of all …
Cytokine storm—definition, causes, and implications
D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …
[HTML][HTML] Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline
JD Chalmers, ML Crichton… - European respiratory …, 2021 - Eur Respiratory Soc
Introduction Hospitalised patients with coronavirus disease 2019 (COVID-19) as a result of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have a high …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have a high …
T cell apoptosis characterizes severe Covid-19 disease
S André, M Picard, R Cezar, F Roux-Dalvai… - Cell Death & …, 2022 - nature.com
Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …
Interleukin-6: obstacles to targeting a complex cytokine in critical illness
OJ McElvaney, GF Curley, S Rose-John… - The Lancet …, 2021 - thelancet.com
Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort
The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major
confounding factors such as age and comorbidities, true mediators of this condition have …
confounding factors such as age and comorbidities, true mediators of this condition have …