Identification of nine new susceptibility loci for endometrial cancer
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract
in developed countries. Through genome-wide association studies (GWAS), we have …
in developed countries. Through genome-wide association studies (GWAS), we have …
Extreme polygenicity of complex traits is explained by negative selection
Complex traits and common diseases are extremely polygenic, their heritability spread
across thousands of loci. One possible explanation is that thousands of genes and loci have …
across thousands of loci. One possible explanation is that thousands of genes and loci have …
Multivariate genome-wide analyses of the well-being spectrum
We introduce two novel methods for multivariate genome-wide-association meta-analysis
(GWAMA) of related traits that correct for sample overlap. A broad range of simulation …
(GWAMA) of related traits that correct for sample overlap. A broad range of simulation …
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits
Multiple methods have been developed to estimate narrow-sense heritability, h 2, using
single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a …
single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a …
Genetic correlates of social stratification in Great Britain
A Abdellaoui, D Hugh-Jones, L Yengo… - Nature human …, 2019 - nature.com
Human DNA polymorphisms vary across geographic regions, with the most commonly
observed variation reflecting distant ancestry differences. Here we investigate the …
observed variation reflecting distant ancestry differences. Here we investigate the …
[HTML][HTML] Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK Biobank
Background Previous studies have related vitamin D supplementation to a lower risk of
acute respiratory tract infection. Emerging evidence suggests that vitamin D insufficiency is …
acute respiratory tract infection. Emerging evidence suggests that vitamin D insufficiency is …
Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism
Neuroticism is a relatively stable personality trait characterized by negative emotionality (for
example, worry and guilt); heritability estimated from twin studies ranges from 30 to 50 …
example, worry and guilt); heritability estimated from twin studies ranges from 30 to 50 …
The Michigan Genomics Initiative: a biobank linking genotypes and electronic clinical records in Michigan Medicine patients
M Zawistowski, LG Fritsche, A Pandit, B Vanderwerff… - Cell Genomics, 2023 - cell.com
Biobanks of linked clinical patient histories and biological samples are an efficient strategy
to generate large cohorts for modern genetics research. Biobank recruitment varies by …
to generate large cohorts for modern genetics research. Biobank recruitment varies by …
Ambient air pollution, healthy diet and vegetable intakes, and mortality: a prospective UK Biobank study
Background Recent studies suggest potential interactions of air pollutants with dietary
factors and genetic susceptibility on mortality risk; however, evidence from prospective …
factors and genetic susceptibility on mortality risk; however, evidence from prospective …
Assessing the pathogenicity, penetrance, and expressivity of putative disease-causing variants in a population setting
More than 100,000 genetic variants are classified as disease causing in public databases.
However, the true penetrance of many of these rare alleles is uncertain and might be over …
However, the true penetrance of many of these rare alleles is uncertain and might be over …