[HTML][HTML] The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private
testing companies to parents using in vitro fertilisation as being useful in selecting the …

Cultural evolution of genetic heritability

R Uchiyama, R Spicer… - Behavioral and Brain …, 2022 - cambridge.org
Behavioral genetics and cultural evolution have both revolutionized our understanding of
human behavior–largely independent of each other. Here, we reconcile these two fields …

[HTML][HTML] Genetic risk factors have a substantial impact on healthy life years

S Jukarainen, T Kiiskinen, S Kuitunen, AS Havulinna… - Nature medicine, 2022 - nature.com
The impact of genetic variation on overall disease burden has not been comprehensively
evaluated. We introduce an approach to estimate the effect of genetic risk factors on …

[HTML][HTML] The impact of rare protein coding genetic variation on adult cognitive function

CY Chen, R Tian, T Ge, M Lam, G Sanchez-Andrade… - Nature Genetics, 2023 - nature.com
Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …

[HTML][HTML] The future of IVF: the new normal in human reproduction

VA Kushnir, GD Smith, EY Adashi - Reproductive Sciences, 2022 - Springer
Increased demand for in vitro fertilization (IVF) due to socio-demographic trends, and supply
facilitated by new technologies, converged to transform the way a substantial proportion of …

[HTML][HTML] The clinical application of polygenic risk scores: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG)

A Abu-El-Haija, HV Reddi, H Wand, NC Rose… - Genetics in …, 2023 - Elsevier
Polygenic inheritance is a non-Mendelian form of inheritance in which the risk of a trait,
disorder, or disease results from the combined contribution of variants from multiple genes …

[HTML][HTML] Open problems in human trait genetics

N Brandes, O Weissbrod, M Linial - Genome Biology, 2022 - Springer
Genetic studies of human traits have revolutionized our understanding of the variation
between individuals, and yet, the genetics of most traits is still poorly understood. In this …

Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits

MC de Hemptinne, D Posthuma - Nature neuroscience, 2023 - nature.com
Genome-wide association studies have led to the identification of robust statistical
associations of genetic variants with numerous brain-related traits, including neurological …

Rank concordance of polygenic indices

D Muslimova, R Dias Pereira, S von Hinke… - Nature Human …, 2023 - nature.com
Polygenic indices (PGIs) are increasingly used to identify individuals at risk of developing
disease and are advocated as screening tools for personalized medicine and education …

Wrestling with social and behavioral genomics: risks, potential benefits, and ethical responsibility

MN Meyer, PS Appelbaum, DJ Benjamin… - Hastings Center …, 2023 - Wiley Online Library
In this consensus report by a diverse group of academics who conduct and/or are concerned
about social and behavioral genomics (SBG) research, the authors recount the often‐ugly …