Pluripotent Stem Cell-Derived In Vitro Gametogenesis and Synthetic Embryos—It Is Never Too Early for an Ethical Debate

S Horer, M Feichtinger, M Rosner… - Stem Cells …, 2023 - academic.oup.com
Recently, 2 branches of the wide area of synthetic biology—in vitro gametogenesis and
synthetic embryo development—have gained considerable attention. Rodent induced …

The uncertain science of preimplantation and prenatal genetic testing

N Gleicher, DF Albertini, P Patrizio, R Orvieto… - Nature medicine, 2022 - nature.com
Tests to identify chromosomal abnormalities in embryos and in early pregnancies are
frequently used to make important decisions, including terminations, but many rely on …

Genome-wide association study of musical beat synchronization demonstrates high polygenicity

M Niarchou, DE Gustavson… - Nature Human …, 2022 - nature.com
Moving in synchrony to the beat is a fundamental component of musicality. Here we
conducted a genome-wide association study to identify common genetic variants associated …

Patient interest in and clinician reservations on polygenic embryo screening: a qualitative study of stakeholder perspectives

D Barlevy, I Cenolli, T Campbell, R Furrer… - Journal of Assisted …, 2024 - Springer
Purpose We explored and compared perspectives of reproductive endocrinology and
infertility specialists (REIs) and in vitro fertilization (IVF) patients regarding polygenic embryo …

Indirect paths from genetics to education

AJ Schork, RE Peterson, A Dahl, N Cai, KS Kendler - Nature Genetics, 2022 - nature.com
The largest genetic study of educational attainment (EA) so far combines gene mapping and
family analyses to show that genetic associations with EA and its health benefits may be …

The economics and econometrics of gene-environment interplay

P Biroli, TJ Galama, S von Hinke… - arXiv preprint arXiv …, 2022 - arxiv.org
Economists and social scientists have debated the relative importance of nature (one's
genes) and nurture (one's environment) for decades, if not centuries. This debate can now …

Ethical layering in AI-driven polygenic risk scores—New complexities, new challenges

MC Fritzsche, K Akyüz, M Cano Abadía… - Frontiers in …, 2023 - frontiersin.org
Researchers aim to develop polygenic risk scores as a tool to prevent and more effectively
treat serious diseases, disorders and conditions such as breast cancer, type 2 diabetes …

Public attitudes, interests, and concerns regarding polygenic embryo screening

RA Furrer, D Barlevy, S Pereira, S Carmi… - JAMA Network …, 2024 - jamanetwork.com
Importance Polygenic embryo screening (PES) is a novel technology that estimates the
likelihood of developing future conditions (eg, diabetes or depression) and traits (eg, height …

Polygenic scores in the direct-to-consumer setting: challenges and opportunities for a new era in consumer genetic testing

JK Park, CY Lu - Journal of Personalized Medicine, 2023 - mdpi.com
Direct-to-consumer (DTC) genetic tests have generated considerable scholarly attention and
public intrigue. Although the current consumer genetic testing regime relies on the reporting …

Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in European countries

M Siermann, V van der Schoot, EM Bunnik… - Human …, 2024 - academic.oup.com
STUDY QUESTION Would the different regulatory approaches for preimplantation genetic
testing (PGT) in Europe permit the implementation of preimplantation genetic testing using …