How not to introduce laboratory tests to clinical practice: preimplantation genetic testing for aneuploidy

N Gleicher, P Patrizio, R Orvieto - Clinical Chemistry, 2022 - academic.oup.com
Laboratory tests fulfill essential functions; 100% accuracy, unfortunately, hardly exists and
validations must verify results within acceptable ranges if tests are not to be considered …

[HTML][HTML] Increasing equity in science requires better ethics training: A course by trainees, for trainees

RA Patel, RA Ungar, AL Pyke, A Adimoelja… - Cell Genomics, 2024 - cell.com
Despite the profound impacts of scientific research, few scientists have received the
necessary training to productively discuss the ethical and societal implications of their work …

Clinical utility of polygenic risk scores for embryo selection: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG)

TA Grebe, G Khushf, JM Greally, P Turley, N Foyouzi… - Genetics in …, 2024 - Elsevier
Polygenic risk score (PRS) assessment for embryo selection (hereafter referred to as
preimplantation testing for polygenic disorder [PGT-P]) is an emerging reproductive …

[PDF][PDF] Ethical, anticipatory genomics research on human behavior means celebrating disagreement

DO Martschenko, S Trejo - Human Genetics and Genomics Advances, 2022 - cell.com
Despite the many social and ethical considerations in human genetics, researchers and
communities remain largely siloed as for-profit, direct-to-consumer genetic testing and the …

[PDF][PDF] Spectrum 10K and the questionable past, present, and future of genetic autism research

HM Natri - Preprint]. ResearchGate. https://doi. org/10.13140/RG, 2021 - researchgate.net
In September 2021, a large-scale autism genomics study Spectrum 10K was paused in
response to feedback from the autistic community. The study is now under review by …

Shared Futures or Financialized Futures: Polygenic Screening, Reproductive Justice, and the Radical Charge of Collective Care

J Denbow, TL Spira - Signs: Journal of Women in Culture …, 2023 - journals.uchicago.edu
Polygenic screening is a new form of embryo testing that assesses the probability that an
embryo will later develop a wide range of health conditions. This technology purports to help …

ISPD 2021 debate‐All in vitro fertilization cycles should involve pre‐implantation genetic testing to improve fetal health and pregnancy outcomes

L Wilkins‐Haug, DJ Amor, J Savulescu - Prenatal Diagnosis, 2022 - Wiley Online Library
For 3 decades, couples at increased risk for a genetic disorder have been offered
preimplantation genetic testing (PGT). Simultaneously, PGT for aneuploidy (PGT‐A) to …

Artificial intelligence as a door opener for a new era of human reproduction

M Hengstschläger - Human Reproduction Open, 2023 - academic.oup.com
The first successful IVF birth in 1978 laid the foundation for the selection of human embryos
prior to their transfer into a uterus. The optimization of this selection process is viewed as …

Perspectives of preimplantation genetic testing patients in Belgium on the ethics of polygenic embryo screening

M Siermann, JR Vermeesch, T Raivio, A Vanhie… - Reproductive …, 2024 - Elsevier
Research question What are the perspectives of preimplantation genetic testing patients in
Belgium on the ethics of preimplantation genetic testing for polygenic risk scoring (PGT-P) …

Polygenic embryo screening: are there potential maternal and fetal harms?

P Ginod, MH Dahan - Reproductive BioMedicine Online, 2023 - Elsevier
Polygenic embryo screening (PES) and its derivate the Embryo Health Score (EHS) has
generated interest in both infertile and fertile populations due to its potential ability to select …