Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Background Infertility is a common reproductive disorder, with male factor infertility
accounting for approximately half of all cases. Taking a paternal perceptive, recent research …

The integration of DNA methylation and transcriptional state within single cells is of broad
interest. Several single-cell dual-and multi-omics approaches have been reported that …

Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes
is unknown. Semen samples from cannabis users and non-user controls were collected at …

Cannabis and cannabinoids are implicated in multiple genotoxic, epigenotoxic and
chromosomal-toxic mechanisms and interact with several morphogenic pathways, likely …

The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological
tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing …

Background Cannabis legalization is expanding and men are the predominant users. We
have limited knowledge about how cannabis impacts sperm and whether the effects are …

Abstract Purpose of Review Cannabis exposure during critical windows of development may
have intergenerational physiological consequences disrupting epigenetic programming and …

Parental age at time of offspring conception is increasing in developed countries. Advanced
male age is associated with decreased reproductive success and increased risk of adverse …