[HTML][HTML] Lessons from the host defences of bats, a unique viral reservoir
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
The Baltimore classification of viruses 50 years later: how does it stand in the light of virus evolution?
SUMMARY Fifty years ago, David Baltimore published a brief conceptual paper delineating
the classification of viruses by the routes of genome expression. The six “Baltimore classes” …
the classification of viruses by the routes of genome expression. The six “Baltimore classes” …
Specialized interferon action in COVID-19
The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both
protective and harmful effects being documented. We report here a multiomics investigation …
protective and harmful effects being documented. We report here a multiomics investigation …
Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease
Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …
[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry
P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
[HTML][HTML] The Egyptian rousette genome reveals unexpected features of bat antiviral immunity
SS Pavlovich, SP Lovett, G Koroleva, JC Guito… - Cell, 2018 - cell.com
Bats harbor many viruses asymptomatically, including several notorious for causing extreme
virulence in humans. To identify differences between antiviral mechanisms in humans and …
virulence in humans. To identify differences between antiviral mechanisms in humans and …
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
[HTML][HTML] HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING
X Luo, CR Donnelly, W Gong, BR Heath… - The Journal of …, 2020 - Am Soc Clin Investig
The incidence of human papillomavirus–positive (HPV+) head and neck squamous cell
carcinoma (HNSCC) has surpassed that of cervical cancer and is projected to increase …
carcinoma (HNSCC) has surpassed that of cervical cancer and is projected to increase …
[HTML][HTML] Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity
M Pujantell, M Altfeld - Frontiers in immunology, 2022 - frontiersin.org
The immune system protects us from pathogens, such as viruses. Antiviral immune
mechanisms aim to limit viral replication, and must maintain immunological homeostasis to …
mechanisms aim to limit viral replication, and must maintain immunological homeostasis to …
[HTML][HTML] Herpes simplex virus 1 infection of neuronal and non-neuronal cells elicits specific innate immune responses and immune evasion mechanisms
AL Verzosa, LA McGeever, SJ Bhark… - Frontiers in …, 2021 - frontiersin.org
Alphaherpesviruses (α-HV) are a large family of double-stranded DNA viruses which cause
many human and animal diseases. There are three human α-HVs: Herpes Simplex Viruses …
many human and animal diseases. There are three human α-HVs: Herpes Simplex Viruses …