The roles of circRNA–miRNA–mRNA networks in the development and treatment of osteoporosis

M Gao, Z Zhang, J Sun, B Li, Y Li - Frontiers in endocrinology, 2022 - frontiersin.org
Osteoporosis is a systemic metabolic disease, mainly characterized by reduced bone
mineral density and destruction of bone tissue microstructure. However, the molecular …

Pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults: a living clinical guideline from the American College of Physicians

A Qaseem, LA Hicks… - Annals of internal …, 2023 - acpjournals.org
An update is available for this article. Description: This guideline updates the 2017 American
College of Physicians (ACP) recommendations on pharmacologic treatment of primary …

Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis

G Long, C Liu, T Liang, Z Zhang, Z Qin… - Journal of Orthopaedic …, 2023 - Springer
Osteoporosis affects more than 200 million women worldwide, with postmenopausal women
being particularly susceptible to this condition and its severe sequelae disproportionately …

Bioinformatics and machine learning were used to validate glutamine metabolism-related genes and immunotherapy in osteoporosis patients

L Wang, C Deng, Z Wu, K Zhu, Z Yang - Journal of Orthopaedic Surgery …, 2023 - Springer
Background Osteoporosis (OP), often referred to as the “silent disease of the twenty-first
century,” poses a significant public health concern due to its severity, chronic nature, and …

[PDF][PDF] Drug efficacy and safety of denosumab, teriparatide, zoledronic acid, and ibandronic acid for the treatment of postmenopausal osteoporosis: a network meta …

WY Wang, LH Chen, WJ Ma… - European Review for …, 2023 - europeanreview.org
OBJECTIVE: This study aims to compare the efficacy and safety of denosumab, teriparatide,
zoledronic acid, and ibandronic acid for the treatment of women with postmenopausal …

Association between obesity and bone mineral density in middle-aged adults

Y Li - Journal of Orthopaedic Surgery and Research, 2022 - Springer
Background The relationship between obesity and bone mineral density (BMD) varies in
different studies. Our aim in this study was to explore the association between obesity (body …

Efficacy of osteoporosis pharmacological treatments in men: a systematic review and meta-analysis

C Beaudart, C Demonceau, S Sabico… - Aging clinical and …, 2023 - Springer
Introduction The objective of this systematic review and meta-analysis is to systematically
identify and review the efficacy of pharmacological treatments in men with osteoporosis …

The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials

L Hu, J Ji, D Li, J Meng, B Yu - Journal of Orthopaedic Surgery and …, 2021 - Springer
Background With the increasing incidence of osteoporosis, vitamin K and calcium have
been linked to bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC) in …

RETRACTED: Trehalose improves palmitic acid‐induced apoptosis of osteoblasts by regulating SIRT3‐medicated autophagy via the AMPK/mTOR/ULK1 pathway

L Cao, S Zhou, X Qiu, S Qiu - The FASEB Journal, 2022 - Wiley Online Library
Accumulation of lipid substances decreased the activity of osteoblasts. Trehalose is a typical
stress metabolite to form a protective membrane on cell surface which has been …

Pharmacological agents for bone fracture healing: talking points from recent clinical trials

F Migliorini, F Cocconi, G Vecchio… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Pharmacological strategies might influence bone healing in terms of time to
union or quality of mature bone. This expert opinion discussed the current level I evidence …