The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …

The liver connects the intestinal portal vasculature with the general circulation, using a
diverse array of immune cells to protect from pathogens that translocate from the gut. In liver …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment
early immune responses and contribute to protection. We hypothesized that MAIT cells may …

Resident memory CD8 T (Trm) cells have been shown to provide effective protective
responses in the small intestine (SI) in mice. A better understanding of the generation and …

Genetically engineered live Plasmodium falciparum sporozoites constitute a potential
platform for creating consistently attenuated, genetically defined, whole-parasite vaccines …

Effector T cells leave the lymph nodes armed with specialized functional attributes. Their
antigenic targets may be located anywhere in the body, posing the ultimate challenge: how …

Chronic hepatitis B infection remains a serious global health threat, contributing to a large
number of deaths through liver cirrhosis and hepatocellular carcinoma. Current treatment …