Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

Lymph nodes (LNs) play critical roles in adaptive immunity by concentrating in one location
the antigens, antigen-presenting cells, and antigen-responsive lymphocytes involved in …

Background Heterologous prime boost immunization with chimpanzee adenovirus 63
(ChAd63) and Modified Vaccinia Virus Ankara (MVA) vectored vaccines is a strategy …

The liver is the target of several infectious, inflammatory, and neoplastic diseases, which
affect hundreds of millions of people worldwide and cause an estimated death toll of more …

Liver-resident memory CD8+ T (T RM) cells remain in and constantly patrol the liver to elicit
rapid immunity upon antigen encounter and can mediate efficient protection against liver …

Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria
infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the …

Tissue‐resident memory T cells (TRM) represent a dedicated layer of localized immune
memory in virtually every organ throughout the human body. By virtue of their long‐term …

Each year malaria kills hundreds of thousands of people and infects hundreds of millions of
people despite current control measures. An effective malaria vaccine will likely be …

A subset of memory T cells has been identified in the liver with a tissue-resident profile and
the capacity for long-term 'lockdown'. Here we review how they are retained in, and adapted …