Tissue-resident memory (TRM) T cells are a unique subset of memory T cells that are critical
for the first line of defense against pathogens or antigens in peripheral non-lymphoid tissues …

Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple
control interventions need to be in place simultaneously to achieve this goal. In addition to …

Introduction: An effective vaccine against malaria forms a global health priority. Both
naturally acquired immunity and sterile protection induced by irradiated sporozoite …

Tissue resident memory T cells (T RM cells) can provide effective tissue surveillance and
can respond rapidly to infection. Vaccination strategies aimed at generating T RM cells have …

Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill
Plasmodium-infected cells. A new malaria vaccine strategy, prime-target vaccination …

Introduction A safe and effective vaccine will likely be necessary for the control or
eradication of malaria which kills 400,000 annually. Our most advanced vaccine candidate …

For some diseases, successful vaccines have been developed using a nonpathogenic
counterpart of the causative microorganism of choice. The nonpathogenicity of the rodent …

Despite recent treatment advances for chronic hepatitis C virus (HCV) infection, a vaccine is
urgently needed for global control of this important liver pathogen. The lack of robust …

While CD4+ T cells are a prerequisite for CD8+ T cell-mediated protection against
intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to …

Each year over 200 million malaria infections occur, with over 400 000 associated deaths.
Vaccines formed with attenuated whole parasites can induce protective memory CD8 T cell …