Despite the licensing of RTS, S/AS01 as the first malaria vaccine by WHO, development of a
durable and efficacious malaria vaccine is still needed to achieve 75% efficacy as targeted …

Malaria is caused by different Plasmodium species that can infect a variety of animals
including humans and rodents. The life cycle of these parasites is complex and includes a …

Chronic infection with Hepatitis B virus (HBV) remains a significant health problem, infecting
millions of people worldwide. Cirrhosis and hepatocellular carcinoma, the sequalae of …

Radiation-attenuated sporozoite (RAS) vaccination offers hope for global malaria control
through induction of protective liver-stage–specific memory CD8 T cells. Effective RAS …

Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can
respond rapidly to infection due to their strategic location. Within the liver, TRM cells can …

The ongoing COVID-19 pandemic has had an enormous impact on societies and highlights
more than ever the need for effective vaccines. High efficacy requires the ability to induce …

Tissue-resident memory T cells (TRM) patrol non-lymphoid organs and provide superior
protection against pathogens that commonly infect mucosal and barrier tissues, such as the …

Malaria is responsible for over 200 million cases and nearly half a million deaths annually.
The successful implementation of control measures resulted in a significant reduction in …

Malaria remains a global public health problem. Traditional vaccine development efforts
spanning many decades have not been successful. Working towards a rationally designed …

The present application relates to novel administration regi mens for poxviral vectors
comprising nucleic acid constructs encoding antigenic proteins and invariant chains. In …