Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Investigating toxin diversity and abundance in snake venom proteomes

T Tasoulis, TL Pukala, GK Isbister - Frontiers in Pharmacology, 2022 - frontiersin.org
Understanding snake venom proteomes is becoming increasingly important to understand
snake venom biology, evolution and especially clinical effects of venoms and approaches to …

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

L Ledsgaard, J Wade, TP Jenkins, K Boddum… - Nature …, 2023 - nature.com
Snakebite envenoming continues to claim many lives across the globe, necessitating the
development of improved therapies. To this end, broadly-neutralizing human monoclonal …

Modern venomics—Current insights, novel methods, and future perspectives in biological and applied animal venom research

BM von Reumont, G Anderluh, A Antunes… - …, 2022 - academic.oup.com
Venoms have evolved> 100 times in all major animal groups, and their components, known
as toxins, have been fine-tuned over millions of years into highly effective biochemical …

A review of the proteomic profiling of African Viperidae and Elapidae snake venoms and their antivenom neutralisation

BC Offor, B Muller, LA Piater - Toxins, 2022 - mdpi.com
Snakebite envenoming is a neglected tropical disease (NTD) that results from the injection
of snake venom of a venomous snake into animals and humans. In Africa (mainly in sub …

Rodent lethality models are problematic for evaluating antivenoms for human envenoming

A Silva, WC Hodgson, T Tasoulis… - Frontiers in …, 2022 - frontiersin.org
Snakebite is a major public health problem in the tropics, being closely associated with
agricultural economy, poverty and underdevelopment. The neglected nature of the condition …

Advances in the therapeutic application of small-molecule inhibitors and repurposed drugs against snakebite: Miniperspective

U Puzari, PA Fernandes… - Journal of Medicinal …, 2021 - ACS Publications
The World Health Organization has declared snakebite as a neglected tropical disease.
Antivenom administration is the sole therapy against venomous snakebite; however, several …

Proteomic and transcriptomic techniques to decipher the molecular evolution of venoms

S Mouchbahani-Constance, R Sharif-Naeini - Toxins, 2021 - mdpi.com
Nature's library of venoms is a vast and untapped resource that has the potential of
becoming the source of a wide variety of new drugs and therapeutics. The discovery of these …

Proteomic Investigation of Cape Cobra (Naja nivea) Venom Reveals First Evidence of Quaternary Protein Structures

LO McFarlane, TL Pukala - Toxins, 2024 - mdpi.com
Naja nivea (N. nivea) is classed as a category one snake by the World Health Organization
since its envenomation causes high levels of mortality and disability annually. Despite this …

Revisiting the potential of South American rattlesnake Crotalus durissus terrificus toxins as therapeutic, theranostic and/or biotechnological agents

MAF Hayashi, JD Campeiro, CM Yonamine - Toxicon, 2022 - Elsevier
The potential biotechnological and biomedical applications of the animal venom
components are widely recognized. Indeed, many components have been used either as …