Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing

HM Sadeghi, I Adeli, D Calina, AO Docea… - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is an endocrine-gynecology disorder affecting many
women of childbearing age. Although a part of the involved mechanism in PCOS occurrence …

Polycystic ovary syndrome: etiology, current management, and future therapeutics

S Singh, N Pal, S Shubham, DK Sarma… - Journal of Clinical …, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically
characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries …

A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)

S Siddiqui, S Mateen, R Ahmad, S Moin - Journal of assisted reproduction …, 2022 - Springer
Polycystic ovarian syndrome (PCOS) is a prevailing endocrine and metabolic disorder
occurring in about 6–20% of females in reproductive age. Most symptoms of PCOS arise …

Progesterone actions and resistance in gynecological disorders

JA MacLean, K Hayashi - Cells, 2022 - mdpi.com
Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain
a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen …

The effects of obesity on the menstrual cycle

K Itriyeva - Current Problems in Pediatric and Adolescent Health …, 2022 - Elsevier
The prevalence of childhood and adolescent obesity has significantly increased in the
United States and worldwide since the 1970s, a trend that has been accelerated by the …

Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis

M Dapas, FTJ Lin, GN Nadkarni, R Sisk, RS Legro… - PLoS …, 2020 - journals.plos.org
Background Polycystic ovary syndrome (PCOS) is a common, complex genetic disorder
affecting up to 15% of reproductive-age women worldwide, depending on the diagnostic …

Fundamental concepts and novel aspects of polycystic ovarian syndrome: expert consensus resolutions

A Aversa, S La Vignera, R Rago, A Gambineri… - Frontiers in …, 2020 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a very common endocrine and metabolic disorder with
the involvement of both genetic and environmental factors. Although much has been …

The role of glp-1 receptor agonists in insulin resistance with concomitant obesity treatment in polycystic ovary syndrome

K Bednarz, K Kowalczyk, M Cwynar, D Czapla… - International journal of …, 2022 - mdpi.com
Insulin resistance is documented in clamp studies in 75% of women with polycystic ovary
syndrome (PCOS). Although it is not included in the diagnostic criteria of PCOS, there is a …

Estrogen-receptor expression and function in female reproductive disease

ZR Tang, R Zhang, ZX Lian, SL Deng, K Yu - Cells, 2019 - mdpi.com
Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-
coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian …

PCOS and depression: common links and potential targets

JV Kolhe, AS Chhipa, S Butani, V Chavda… - Reproductive …, 2022 - Springer
PCOS or polycystic ovary syndrome is a common endocrine disorder that occurs during the
reproductive age in females. It manifests in the form of a wide range of symptoms including …