Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …

Chronic kidney disease (CKD) is a major public health concern, underscoring a need to
identify pathogenic mechanisms and potential therapeutic targets. Reactive oxygen species …

Smoking is recognized as a significant risk factor for numerous disorders, including
cardiovascular diseases, respiratory conditions, and various forms of cancer. While the exact …

Nitric oxide (NO) plays an important and diverse signalling role in the cardiovascular system,
contributing to the regulation of vascular tone, endothelial function, myocardial function …

Increased life expectancy, attributed to improved access to healthcare and drug
development, has led to an increase in multimorbidity, a key contributor to polypharmacy …

Under specific conditions, such as catabolic stress or systemic inflammation, endogenous
nutrient production becomes insufficient and exogenous supplementation (eg., through …

The endothelium is a monocellular layer covering the inner surface of blood vessels. It
maintains vascular homeostasis regulating vascular tone and permeability and exerts anti …

Numerous natural antioxidants commonly found in our daily diet have demonstrated
significant benefits for human health and various diseases by counteracting the impact of …

Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …

Hypertension, or high blood pressure (BP), is a complex disease influenced by various risk
factors. It is characterized by persistent elevation of BP levels, typically exceeding 140/90 …