We demonstrate, for the first time, that the transcription factor NF-κB is constitutively activated
during human cervical cancer progression. Immunohistochemical analysis was done using …

Pdcd4 is a novel transformation suppressor that is highly expressed in promotion-resistant
(P−) mouse epidermal JB6 cells but not in susceptible (P+) cells. Overexpression of pdcd4 …

Transformation suppressor Pdcd4 is downregulated in transformed (Tx) mouse epidermal
JB6 RT101 cells relative to transformation-resistant (P−) and susceptible (P+) variants …

AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key
regulators of epidermal keratinocyte survival and differentiation and important drivers of …

A simple and novel electrochemical sensor for the determination of tetracycline (TC), a kind
of antibiotic that may induce residue in the food chain, was developed by the modification of …

Tumour necrosis factor-α (TNF-α) deficient mice (TNF-α−/− mice) are resistant to skin
carcinogenesis. Cellular signalling via the transcription factor complex AP-1 is thought to …

There are still many unanswered questions regarding the processes by which extracellular
signals are transduced from plasma-membrane receptors to the transcription machinery in …

Tonicity-responsive binding-protein (TonEBP or NFAT5) is a widely expressed transcription
factor whose activity is regulated by extracellular tonicity. TonEBP plays a key role in …

Mounting evidence suggests a role for matrix metalloproteinase (MMP)-2 in the malignant
progression of breast cancer cells. We showed previously that H-Ras, but not N-Ras …

Many tumors show a mutant or inactive tumor suppressor p53 (TP53) status, and TP53 in the
tumor-carrying human papillomavirus (HPV) may be dysfunctional because of inhibition by …