To circumvent carrier related obstacles, we developed a biodegradable, folate conjugated
poly (ester amine)(FP-PEA) that mediates high level folate receptor (FR) mediated …

AP-1, a transcription factor comprised primarily of Jun and Fos family proteins, regulates
genes involved in proliferation, differentiation and oncogenesis. Previous studies …

Abstract AP-1 and NF-κB are rapidly activated during liver regeneration. Whether these
parallel inductions have potential functional implications is not known. Isolated rat …

Among the effector molecules connected with the group of cell surface receptors, Ras
proteins have essential roles in transducing extracellular signals to diverse intracellular …

Invasion is generally perceived to be a late event during the progression of human cancer,
but to date there are no consistent reports of alterations specifically associated with …

Studies have demonstrated bile acids, principally deoxycholic acid (DCA), to be colon tumor
promoters. DCA is cytotoxic and increasing evidence suggests a role for DCA-induced …

Lung cancer is the leading cause of cancer mortality in the United States and worldwide.
The identification of key regulatory and molecular mechanisms involved in lung …

Expression of the human papillomavirus (HPV) type 16 E6 and E7 gene products is a risk
factor for human cervical carcinogenesis as well as skin and oral carcinogenesis …

Potential targets for chemoprevention of nonmelanoma skin cancer include UV‐induced
nuclear factor κB (NF‐κB) and activator protein‐1 (AP‐1) activation in keratinocytes …

Protein arginine methyltransferase 5 (PRMT5) is a key epigenetic regulator that
symmetrically dimethylates arginine residues on histones H3 and H4 to silence gene …