[HTML][HTML] Long COVID and its Management

HC Koc, J Xiao, W Liu, Y Li, G Chen - International Journal of …, 2022 - ncbi.nlm.nih.gov
The pandemic of COVID-19 is the biggest public health crisis in 21 st Century. Besides the
acute symptoms after infection, patients and society are also being challenged by the long …

Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis

NNY Tsang, HC So, KY Ng, BJ Cowling… - The Lancet Infectious …, 2021 - thelancet.com
Background The comparative performance of different clinical sampling methods for
diagnosis of SARS-CoV-2 infection by RT-PCR among populations with suspected infection …

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

MI Barton, SA MacGowan, MA Kutuzov, O Dushek… - Elife, 2021 - elifesciences.org
(RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in
the RBD are present in SARS-CoV-2 variants of concern that have emerged independently …

Extrapulmonary manifestations of COVID-19

A Gupta, MV Madhavan, K Sehgal, N Nair… - Nature medicine, 2020 - nature.com
Although COVID-19 is most well known for causing substantial respiratory pathology, it can
also result in several extrapulmonary manifestations. These conditions include thrombotic …

COVID-19 and the elderly: insights into pathogenesis and clinical decision-making

F Perrotta, G Corbi, G Mazzeo, M Boccia… - Aging clinical and …, 2020 - Springer
The elderly may represent a specific cluster of high-risk patients for developing COVID-19
with rapidly progressive clinical deterioration. Indeed, in older individuals …

Prevalence of comorbidities among individuals with COVID-19: A rapid review of current literature

KT Bajgain, S Badal, BB Bajgain, MJ Santana - American journal of …, 2021 - Elsevier
Introduction On February 11, 2020 WHO designated the name “COVID-19” for the disease
caused by “severe acute respiratory syndrome coronavirus 2”(SARS-CoV-2), a novel virus …

A randomized clinical trial of the efficacy and safety of interferon β-1a in treatment of severe COVID-19

E Davoudi-Monfared, H Rahmani… - Antimicrobial agents …, 2020 - Am Soc Microbiol
To the best of our knowledge, there is no published study on the use of interferon β-1a (IFN
β-1a) in the treatment of severe COVID-19. In this randomized clinical trial, the efficacy and …

Postdischarge thrombosis and hemorrhage in patients with COVID-19

R Patell, T Bogue, A Koshy, P Bindal… - Blood, The Journal …, 2020 - ashpublications.org
Abstract Coronavirus disease 2019 (COVID-19) is associated with a prothrombotic state with
a high incidence of thrombotic events during hospitalization; however, data examining rates …

Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications

JT Merrill, D Erkan, J Winakur, JA James - Nature Reviews …, 2020 - nature.com
Reports of widespread thromboses and disseminated intravascular coagulation (DIC) in
patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number …

[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy

PK Datta, F Liu, T Fischer, J Rappaport, X Qin - Theranostics, 2020 - ncbi.nlm.nih.gov
The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …