Mitochondrial DNA (mtDNA) is a maternally inherited, high-copy-number genome required
for oxidative phosphorylation. Heteroplasmy refers to the presence of a mixture of mtDNA …

Despite the high prevalence of snoring in Asia, little is known about the genetic etiology of
snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese …

Genome-wide association studies (GWASs) have identified numerous variants associated
with polygenic traits and diseases. However, with few exceptions, a mechanistic …

Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked
to type 2 diabetes and obesity, identified> 20 associated loci. However, most loci were …

Identifying causal genes at GWAS loci can help pinpoint targets for therapeutic interventions.
Expression studies can disentangle such loci but signals from expression quantitative trait …

Inadequate representation of non-European ancestry populations in genome-wide
association studies (GWAS) has limited opportunities to isolate functional variants. Fine …

Fine-mapping prioritizes risk variants identified by genome-wide association studies
(GWASs), serving as a critical step to uncover biological mechanisms underlying complex …

Identifying causal genes underlying genome-wide association studies (GWAS) is a
fundamental problem in human genetics. Although colocalisation with gene expression …

Human height can be divided into sitting height and leg length, reflecting growth of different
parts of the skeleton whose relative proportions are captured by the ratio of sitting to total …

Leveraging data from multiple ancestries can greatly improve fine-mapping power due to
differences in linkage disequilibrium and allele frequencies. We propose MultiSuSiE, an …