Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …

The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

In response to infection or sterile insults, inflammatory programmed cell death is an essential
component of the innate immune response to remove infected or damaged cells …

Acquired mutations in the UBA1 gene were recently identified in patients with severe adult-
onset auto-inflammatory syndrome called VEXAS (vacuoles, E1 enzyme, X-linked …

Ischemic stroke (IS) accounts for more than 80% of the total stroke, which represents the
leading cause of mortality and disability worldwide. Cerebral ischemia/reperfusion injury …

PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized
by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone …

Type I interferons (IFNs) are essential innate immune proteins that maintain tissue
homeostasis through tonic expression and can be upregulated to drive antiviral resistance …

Cell death is a fundamental pathophysiological process in human disease. The discovery of
necroptosis, a form of regulated necrosis that is induced by the activation of death receptors …

Disruption of the intestinal epithelial barrier is a hallmark of mucosal inflammation. It
increases exposure of the immune system to luminal microbes, triggering a perpetuating …