Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …

Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …

Fluorescence microscopy, with its molecular specificity, is one of the major characterization
methods used in the life sciences to understand complex biological systems. Super …

Monoclonal antibodies (mAbs) targeting human antigen CD20 (cluster of differentiation 20)
constitute important immunotherapies for the treatment of B cell malignancies and …

The immune system plays a significant role in multiple sclerosis. While MS was historically
thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells …

Objectives Autologous chimeric antigen receptor (CAR) αβ T‐cell therapies have
demonstrated remarkable antitumor efficacy in patients with haematological malignancies; …

With conformation-specific nanobodies being used for a wide range of structural,
biochemical, and cell biological applications, there is a demand for antigen-binding …

Ocrelizumab, rituximab, ofatumumab, ublituximab, inebilizumab, and evobrutinib are
immunotherapies that target various B cell–related proteins. Most of these treatments have …

Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied
the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated …

Ferroptosis is an iron-dependent form of cell death driven by biochemical processes that
promote oxidation within the lipid compartment. Calcium (Ca2+) is a signaling molecule in …