The African continent is poised to have a pivotal role in the global population landscape,
with the United Nations projecting a population of 2.5 billion (more than 25% of the global …

Hereditary hearing loss is both clinically and genetically very heterogeneous. Despite the
large number of genes that have been associated with the condition, many cases remain …

Mutations in GJB2, the gene that encodes connexin 26 (Cx26), are the most common cause
of sensorineural hearing impairment. The truncating variant 35delG, which determines a …

Experimental and clinical data suggest a tight link between hearing and cognitive functions
under both physiological and pathological conditions. Indeed, hearing perception requires …

Background Redox imbalance and inflammation have been proposed as the principal
mechanisms of damage in the auditory system, resulting in functional alterations and …

Intrinsically generated neural activity propagates through the developing auditory system to
promote maturation and refinement of sound processing circuits prior to hearing onset. This …

Connexin 26 and connexin 30 are the prevailing isoforms in the epithelial and connective
tissue gap junction systems of the developing and mature cochlea. The most frequently …

The pathophysiology of age‐related hearing loss (ARHL), or presbycusis, involves a
complex interplay between environmental and genetic factors. The fundamental …

Mutations in connexins are the most common causes of hearing impairment (HI) in many
populations. Our aim was to review the global burden of pathogenic and likely pathogenic …

Background Recessive mutations in GJB2 is the most common cause of genetic hearing
loss worldwide. The aim of this study is to determine the spectrum and frequency of GJB2 …