Facing the explosive growth of biological sequence data, such as those of protein/peptide
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

Information about the interactions of drug compounds with proteins in cellular networking is
very important for drug development. Unfortunately, all the existing predictors for identifying …

ABSTRACT A clinical Escherichia coli isolate resistant to all β-lactams, including
carbapenems, expressed a novel metallo-β-lactamase (MBL), NDM-4, differing from NDM-1 …

Abstract Development of antibiotic resistance (ABR) in bacteria and its multidimensional
spread is an emerging global threat that needs immediate attention. Extensive antibiotics …

Owing to their unique functions in regulating glucose, lipid and cholesterol metabolism,
PPARs (peroxisome proliferator-activated receptors) have drawn special attention for …

The worldwide spread of H1N1 avian influenza and the increasing reports about its
resistance to the current drugs have made a high priority for developing new anti-influenza …

Controlling microorganism outbreaks is a critical challenge in preventing the spread of
infectious diseases. In addition, an increase in drug-resistant bacterial strains came from …

Nuclear receptors (NRs) are closely associated with various major diseases such as cancer,
diabetes, inflammatory disease, and osteoporosis. Therefore, NRs have become a frequent …

Transmissible spongiform encephalopathies (TSEs) are prion protein misfolding diseases
that involve the accumulation of an abnormal β-sheet-rich prion protein aggregated form …