Targeting macrophages in organ transplantation: A step toward personalized medicine

MC Owen, BJ Kopecky - Transplantation, 2024 - journals.lww.com
Organ transplantation remains the most optimal strategy for patients with end-stage organ
failure. However, prevailing methods of immunosuppression are marred by adverse side …

Prolonged inhibition of the MEK1/2-ERK signaling axis primes interleukin-1 beta expression through histone 3 lysine 9 demethylation in murine macrophages

R Low, SD Ha, N Sleapnicov, P Maneesh… - International Journal of …, 2023 - mdpi.com
Macrophages undergo different cellular states upon activation that can be hyporesponsive
(tolerated) or hyperresponsive (primed or trained) to subsequent stimuli. Epigenetic …

Effects of N‐acetyl‐L‐cysteine polysulfides on periodontitis in a mouse model

X Sun, Y Sun, S Cao, X Liu - Immunity, Inflammation and …, 2023 - Wiley Online Library
Background Polysulfides are reported to be involved in various important biological
processes. N‐acetyl‐l‐cysteine polysulfide with 2 sulfane sulfur atoms (NAC‐S2) regulates …

miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2

C Zheng, H Su, M Liu, Y Qian… - Biomedical …, 2024 - spandidos-publications.com
Chronic hepatitis B virus (HBV) infection is a critical causative factor in the tumorigenesis
and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) serve a critical …

Prolonged Inhibition of the MEK1/2-ERK Signaling Axis Primes IL-1β Expression through H3K9 Demethylation in Murine Macrophages

R Low, SD Ha, N Sleapnicov, P Maneesh, S ouk Kim - 2023 - preprints.org
Macrophages undergo different cellular states upon activation that can be hyporesponsive
(tolerated) or hyperresponsive (primed or trained) to subsequent stimuli. Epigenetic …

The Role of the MEK1/2-ERK-RSK Signalling Axis in Innate Immune Memory

R Low - 2023 - search.proquest.com
Macrophages are innate immune cells that change their cellular states in response to
different stimuli. This process is referred to as “innate immune memory” which can render …

[图书][B] Investigating novel mechanisms for transcriptional memory using genetic engineering

YP Sanchez - 2023 - search.proquest.com
Transcriptional memory is phenomenon that has gained interest due to its potential impact
on human health. With our work, we wanted to contribute to the understanding of its …