Simple Summary Despite an initial response to therapy, many lung cancer patients
inevitably develop resistance to therapy leading to decreased duration of response and …

Chemoresistance including intrinsic and acquired anticancer drug resistance continues to
be a primary hindrance towards curative cancer treatment. Therefore, deciphering the …

NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer
therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF …

Combination chemotherapy is a promising strategy for cancer treatment in clinics especially
when multidrug-resistant cancer is emerging. One significant challenge remains in …

Pancreatic ductal adenocarcinoma (PDAC) has one of the highest incidence/death ratios
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …

Cancer cell metabolism including aerobic glycolysis, amino acid and fatty acid metabolism,
has been extensively studied. Metabolic reprogramming is a major hallmark of cancer …

Ovarian cancer is the fifth cause of cancer-related deaths in women with high grade serous
carcinoma (HGSOC) representing the most common histological subtype. Approximately …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Mesoporous silica nanocarrier (MSN) preparations have a wide range of medical
applications. Studying the biocompatibility of MSN is an important part of clinical …

Liver metastasis is one of the major causes of colorectal cancer (CRC)-related morbidity and
mortality. Delivering small interfering RNAs (siRNAs) or noncoding RNAs has been reported …