In recent decades, increasing interest in the use of natural products in anticancer therapy
field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral …

Glioblastoma (GBM) represents the main form of brain tumors in adults, and one of the most
aggressive cancers overall. The treatment of GBM is a combination of surgery (when …

Basic and clinical cancer research requires tumor models that consistently recapitulate the
characteristics of prima tumors. As ex vivo 3D cultures of patient tumor cells, patient‐derived …

Here we discuss approaches to K-Ras inhibition and drug resistance scenarios. A
breakthrough offered a covalent drug against K-RasG12C. Subsequent innovations …

Nanomedicine employs nanotechnologies to develop innovative applications, and more
specifically nano-objects in the field of human health, through exploitation of the physical …

Despite some advances in targeted therapeutics of human cancers, curative cancer
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …

Multidrug resistance (MDR) poses a significant obstacle to effective cancer treatment, and
the tumor microenvironment (TME) is crucial for MDR development and reversal. The TME …

Multidrug resistance (MDR) is one of the main reasons for the failure of tumor chemotherapy
and has a negative influence on the therapeutic effect. MDR is primarily attributable to two …

The intracellular redox homeostasis is a dynamic balancing system between the levels of
free radical species and antioxidant enzymes and small molecules at the core of cellular …

Chemotherapy continues to be a major treatment strategy for various human malignancies.
However, the frequent emergence of chemoresistance compromises chemotherapy efficacy …