Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder
associated with a defect in platelet function, technologic advances helped investigators …

Binding of fibrinogen to platelet integrin αIIbβ3 mediates platelet aggregation, and thus
inhibition of αIIbβ3 represents a powerful therapeutic strategy in cardiovascular medicine …

T cell proliferative responses to platelet membrane GPIIb-IIIa were examined in 14 patients
with chronic immune thrombocytopenic purpura (ITP), 7 systemic lupus erythematosus (SLE) …

MDC-15 (ADAM-15, metargidin), a membrane-anchored metalloprotease/disintegrin/
cysteine-rich protein, is expressed on the surface of a wide range of cells and has an RGD …

Integrin adhesion receptors are structurally dynamic proteins that adopt a number of
functionally relevant conformations. We have produced a conformation-dependent anti-α5 …

The platelet integrin αIIbβ3 is essential for hemostasis and thrombosis through its binding of
adhesive plasma proteins. We have determined crystal structures of the αIIbβ3 headpiece in …

Residues important in the interaction between the 23-residue transmembrane (TM) domains
of the integrin αIIb-and β3-subunits were identified by mutating each non-Leu residue to …

Adhesion to extracellular ligands through integrins regulates cell shape, migration, growth,
and survival. How integrins transmit signals in the outside-to-in direction remains unknown …

Integrin α v β 3 recognizes fibrinogen γ and α E chain C-terminal domains (γC and α EC) but
does not require the γC dodecapeptide sequence HHLGGAKQAGDV 400–411 for binding to …

A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin
αIIbβ3 cannot be achieved without compromising hemostasis, thus causing serious bleeding …