Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

SL Pulit, LC Weng, PF McArdle, L Trinquart… - Neurology …, 2018 - AAN Enterprises
Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can
explain cardioembolic stroke risk. Methods We evaluated genetic correlations between a …

Polygenic Risk Score associated with specific symptom dimensions in first-episode psychosis

SM Sengupta, K MacDonald, F Fathalli, A Yim… - Schizophrenia …, 2017 - Elsevier
Abstract Recent Genome-Wide Association Studies (GWAS) have provided evidence for the
involvement of a number of genetic variants in schizophrenia (SCZ). The objective of the …

Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis

TL Warren, JD Tubbs, TA Lesh, MB Corona… - Molecular …, 2024 - nature.com
A primary goal of psychiatry is to better understand the pathways that link genetic risk to
psychiatric symptoms. Here, we tested association of diagnosis and endophenotypes with …

Facial emotion recognition in psychosis and associations with polygenic risk for schizophrenia: Findings from the multi-center EU-GEI case–control study

G Tripoli, D Quattrone, L Ferraro… - Schizophrenia …, 2022 - academic.oup.com
Abstract Background and Hypothesis Facial Emotion Recognition is a key domain of social
cognition associated with psychotic disorders as a candidate intermediate phenotype. In this …

Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study

B Pignon, H Peyre, A Ayrolles, JB Kirkbride… - Epidemiology and …, 2022 - cambridge.org
Aims Gene x environment (G× E) interactions, ie genetic modulation of the sensitivity to
environmental factors and/or environmental control of the gene expression, have not been …

Polygenic risk associated with post-traumatic stress disorder onset and severity

B Misganaw, G Guffanti, A Lori, D Abu-Amara… - Translational …, 2019 - nature.com
Post-traumatic stress disorder (PTSD) is a psychiatric illness with a highly polygenic
architecture without large effect-size common single-nucleotide polymorphisms (SNPs) …

The relative and interactive impact of multiple risk factors in schizophrenia spectrum disorders: a combined register-based and clinical twin study

C Lemvigh, R Brouwer, R Hilker, S Anhøj… - Psychological …, 2023 - cambridge.org
Background Research has yielded evidence for genetic and environmental factors
influencing the risk of schizophrenia. Numerous environmental factors have been identified; …

[HTML][HTML] A genome-wide association study and polygenic risk score analysis of posttraumatic stress disorder and metabolic syndrome in a south african population

PC Swart, LL Van den Heuvel, CM Lewis… - Frontiers in …, 2021 - frontiersin.org
Posttraumatic stress disorder (PTSD) is a trauma-related disorder that frequently co-occurs
with metabolic syndrome (MetS). MetS is characterized by obesity, dyslipidemia, and insulin …

The lived experience of first-episode psychosis: A systematic review and metasynthesis of qualitative studies

A Noiriel, L Verneuil, I Osmond, E Manolios… - …, 2020 - karger.com
Both research and care have focused on first episodes of psychosis (FEPs) as a way to
address the issue of early stages of schizophrenia and to reduce the duration of untreated …

Discriminating bipolar depression from major depressive disorder with polygenic risk scores

DT Liebers, M Pirooznia, A Ganna, FS Goes - Psychological …, 2021 - cambridge.org
Background Although accurate differentiation between bipolar disorder (BD) and unipolar
major depressive disorder (MDD) has important prognostic and therapeutic implications, the …